A Review of Cisplatin-Associated Ototoxicity
نویسندگان
چکیده
منابع مشابه
Cisplatin-Associated Ototoxicity: A Review for the Health Professional
Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient's quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin's ototoxic properties and the clinical signs to identify patients at ...
متن کاملMechanisms of cisplatin ototoxicity: theoretical review.
INTRODUCTION Cisplatin is an effective chemotherapeutic agent commonly used in the treatment of malignant tumours, but ototoxicity is a significant side effect. OBJECTIVES To discuss the mechanisms of cisplatin ototoxicity and subsequent cell death, and to present the results of experimental studies. MATERIAL AND METHODS We conducted a systematic search for data published in national and in...
متن کاملA Dose-Effect Study of Cisplatin Ototoxicity in Albino Guinea Pigs
Introduction: Cisplatin is one of the most commonly used antineoplastic drugs; nonetheless, its ototoxic dose-limiting side effects have remained a significant challenge in clinical practice. The recognition of the exact template of hearing loss induced by multiple low doses of cisplatin could be of great help in managing the treatment process. The present study aimed to investigate the e...
متن کامل[Genetic background of cisplatin induced ototoxicity].
BACKGROUND Cisplatin induced ototoxicity is a serious adverse effect of cisplatin therapy. Cisplatin induced ototoxicity shows significant interindividual variability. This variability is probably based on genetic background. Recent papers describe association of cisplatin ototoxicity with allelic variants of glutathion-S-transferase coding genes. PATIENTS AND METHODS We have analyzed 55 pati...
متن کاملMechanisms of Cisplatin-Induced Ototoxicity and Otoprotection
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) in cell of the cochlea, which led to the development of various antioxidants a...
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ژورنال
عنوان ژورنال: Seminars in Hearing
سال: 2019
ISSN: 0734-0451,1098-8955
DOI: 10.1055/s-0039-1684041